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Deliverability and reputation problems can occur if you are using a shared IP address to send out your emails while other senders use the same IP address. If the other senders emails get marked as spam or the shared IP address gets blacklisted your IP will be blacklisted and/or your emails will land in the junk folder. Many ESPs automatically use shared IP addresses across many clients.

Lead Liaison assigns a dedicated IP address to each customer. Trials are run using a shared IP address pool. Even in the pool, there are multiple IP addresses to prevent one from going down and affecting other trials.

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Sender ID/SPF prevents other people/servers from pretending to be you. Sender Policy Framework (SPF) is similar to DomainKeys/DKIM since it validates you as the sender; however, the implementation is different from DomainKeys/DKIM. SPF works by publishing what is called a "reverse MX" record to tell the Image Removed Image Added internet what machines are allowed to send mail from the domain.
Sender ID and SPF are different. Both validate email sender addresses using similar methods, publish records in DNS and use the same syntax for their policy records. They are different in what they validate and the layer of the email system they check.
Sender ID and SPF is configured outside of Lead Liaison and should be done by your company. The setup requires changing your DNS record. You can check where your DNS is hosted here: http://whois.domaintools.com/http://whois.domaintools.com/ and possibly enlist support from your DNS host to help you change the record.
There are wizard's to help configure SPF and Sender ID available here:

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